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Bromhexine is a cough medication, available over-the-counter in much of the world, that has been proposed as a COVID-19 therapeutic.

Potential mechanism of action

In an NIH study, bromhexine did not directly inhibit the TMPRSS2 enzyme.

Bromhexine has been speculated to inhibit the TMPRSS2 serine protease used by SARS-CoV-2.

In an August 6th, 2020 NIH paper, bromhexine did not directly inhibit TMPRSS2 in vitro.  Study author Matt Hall noted:

"The fact bromhexine is not inhibiting TMPRSS2 doesn't mean it can't work against COVID, and other recent literature in cell models supports our data." -Matt Hall, NIH researcher

COVID-19 clinical trials

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See also