If ARBs (or other drugs modulating the renin-angiotensin system) help in COVID-19, what would be the ideal dosing and medication to use? This page explores this question.
Dose & medication used in clinical trials
- Losartan:
- 12.5mg bid. 200 participants total.
- 25mg od for 14 days. Multi-arm trial, estimate ~1000 participants total.
- 25mg od for 10 days. 580 participants total.
- 25mg bid. 20 participants total.
- 25mg bid for 14 days. 100 participants total.
- 25 od, escaled to 50mg. 34 participants total.
- 50mg od. 200 participants total.
- 50mg od for 15 days. 176 participants total.
- 100mg od. Multi-arm trial, estimate ~5000 participants.
- Titration up to 100mg od over 3 days. 1372 participants total.
- Valsartan:
- Telmisartan:
- Candesartan:
- Unspecified ARB/dose: